intermittent vs continuous lasix

Intermittent Bolus Injection versus Continuous Infusion of Furosemide in Normal Adult Greyhound Dogs Darcy B. Adin, Aaron W. Taylor, Richard C. Hill, Karen C. Scott, and Frank G. Martin Several studies in human subjects have demonstrated greater diuresis with constant rate infusion (CRI) furosemide than intermittent bolus (IB) furosemide. Several studies have examined the potential benefits of continuous vs intermittent (bolus) intravenous loop diuretic administration in hospitalized patients with conflicting results. CHEST I 102 I 3 I SEPTEMBER. Serving as an easy-to-use, comprehensive clinical reference, the text takes an evidence-based approach to detailed coverage of specific diseases and disorders, including etiology and prevalence, clinical signs, diagnosis, treatment, ... However, in another four studies using continuous furosemide infusion as control treatment, only one study (Brown ) was reported as ARF, and an extremely high dose of furosemide was used in this study (1000 mg/24 h, bolus vs 3000 mg/24 h, continuous). Continuous vs thrice-daily ceftazidime for elective intravenous antipseudomonal therapy in cystic fibrosis. Hubert D, Le Roux E, Lavrut T, et al. Crossref Medline Google Scholar The DOSE trial was a multi centre randomised study but was also underpowered to conclude on mortality difference. The infusion rate was doubled every 2 hours (to a maximum of 0.4 mg/kg/hr) if … Physiologic data suggest that intermittent high-dose furosemide promotes neurohormonal activation, which a slow continuous infusion might remediate. View at Publisher | View at Google Scholar High-dose furosemide in the treatment of refractory congestive heart failure. Recently published randomized control trials (RCTs) have further questioned our understanding of RRT in critical care. Overall, furosemide seems to be a more widely used agent in critical care – so we will focus a bit more on it here. Researchers conducted a new meta-analysis of 10 randomized clinical trials (total patients, 564) to compare the effects of continuous infusion and intermittent bolus of furosemide. In addition, continuous infusion appears to provide more efficient diuresis. Found inside – Page 206For continuous rate infusion, furosemide is diluted in 0.9% saline solution ... treatment may be continued with intermittent bolus dosing of furosemide (0.5 ... 10 12 14 18 • 20 22 24 28 28 30 32 34 38 38 40 42 44 48 48Houra Handbook offers information compiled from the UK Renal Pharmacy Group and features drug monographs guiding physicians in how to prescribe, prepare, and administer drugs to patients undergoing renal replacement therapy. The only comprehensive work to cover all aspects of diuretic agents, the book discusses the pharmacology and toxicology of diuretic agents as well as the physiological effects. Continuous Versus Intermittent Furosemide Infusion in Critically Ill Infants After Open Heart Operations Giovanni Battista Luciani, MD, Sanjiv Nichani, MB, Anthony C. Chang, MD, Winfield J. Efficiently skim through many trials at a time. In addition, continuous infusion appears to provide more efficient diuresis. Alqahtani F, Koulouridis I, Susantitaphong P, et al. However, if a continuous infusion is used, it is important to begin with a bolus to assure that the patient is diuretic responsive and to achieve therapeutic drug concentrations. Physiologic data suggest that intermittent high-dose furosemide promotes neurohormonal activation, which a slow continuous infusion might remediate. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy. Continuous infusion was associated with greater weight loss, increased total urine output in 24 h and BNP reduction when compared with intermittent bolus. Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. To date there are many controlled studies which have effectively compared the efficacy of intermittent intravenous bolus administration of a loop diuretic with continuous infusion in patients with advanced heart failure. J Card Fail. Background: Currently, there are no meta-analyses evaluating the efficacy and safety of intermittent vs continuous furosemide for heart failure concomitant renal dysfunction. Development of an optimal furosemide infusion strategy in infants with modeling … 2011 Mar 3;364(9):797-805, Cochrane Database Syst Rev. Continuous versus intermittent infusions … Arch Intern Med 1988; 148: 286-91. Several studies in human subjects have demonstrated greater diuresis with constant rate infusion (CRI) furosemide than intermittent bolus (IB) furosemide. Practical clinical handbook reviewing all aspects of the diagnosis and management of intra-abdominal hypertension; essential reading for all critical care staff. Effect of admission oral diuretic dose on response to continuous versus bolus intravenous diuretics in acute heart failure: an analysis from 10. And although there are a number of intravenous agents that can be used for acute decompensated heart failure, there are no national guidelines currently available. Edited by a well-known expert and his team of con 4. Proportion that received high-dose furosemide in trial: 80% vs … 46 Lahav M, Regev A, Raanani P, Theodor E. Intermittent administration of furosemide vs continuous infusion preceded by a loading dose for congestive-heart-failure. Found inside – Page 658In a study comparing continuous rate infusion (CRI) to intermittent administration (IA) of furosemide in the horse, CRI of the drug produced more uniform ... Continuous infusion versus intermittent bolus furosemide in ADHF: An updated meta-analysis of randomized control trials Muhammad Amer, Jurga Adomaityte, Rehan Qayyum School of Medicine This study was conducted to compare the diuretic efficacy of the same total dose of IB furosemide and CRI furosemide in 6 healthy, adult Greyhound dogs in a randomized crossover design with a 2-week washout period between treatments. Read "Intermittent administration of furosemide or continuous infusion in critically ill infants and children: does it make a difference?, Intensive Care Medicine" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Lower in continuous vs intermittent infusion of furosemide Between 2 and 15 mg/h Difficult to suggest optimal regimen as variety of regimens used in different studies Acute renal injury not seen Supraventricular tachycardia with continuous infusions 0.075–0.2 mg/kg/h up to a maximum of 0.4 mg/kg/h All studies had a relatively small sample Continuous versus intermittent use of furosemide in patients with heart failure and moderate chronic renal dysfunction. REVIEWS Continuous Infusion Versus Intermittent Bolus Furosemide in ADHF: An Updated Meta-Analysis of Randomized Control Trials Muhammad Amer, MD1*,Jurga Adomaityte, MD2 Rehan Qayyum, MD, MHS1 1Division of General Internal Medicine/Hospitalist Program, Johns Hopkins School of Medicine, Baltimore, Maryland; 2Sinai/Johns Hopkins University Internal Medicine Residency Program, Sinai … Found inside – Page 448Effect of bolus injection versus continuous infusion of furosemide on diuresis and neu- rohormonal activation in patients with severe congestive heart ... PubMed journal article: Diuretic treatment in high-risk acute decompensation of advanced chronic heart failure-bolus intermittent vs. continuous infusion of furosemide: a randomized controlled trial. These issues are … 1.11 Give Furosemide slowly, a rate of 4mgs per minute should not be exceeded 1.12 Wipe end of infusion device with disinfection wipe provided allow to dry 1.13 Flush 5mls sodium chloride (slowly as drug in the line) and finish with positive pressure. Print+CourseSmart " This is a well written, comprehensive review aimed at preparing readers for successfully completing a board certification exam. Several controlled studies have compared the efficacy of intermittent intravenous bolus administration of a loop diuretic with continuous infusion in patients with advanced heart failure. Download Prime PubMed App to iPhone, iPad, or Android and Yap, J.L.L. However, the limited clinical data comparing dosing schemes are confounded. Comparison of continuous versus intermittent furosemide administration in dogs with acute heart failure Zita Filipejová, Carlos Fernando Agudelo Ramírez, Michal Crha University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Small Animal Clinic, Brno, Czech Republic Received April 11, 2016 Accepted June 23, 2016 In addition to uncertainty about dosing, there is uncertainty about the optimal mode of administration. Pharmacokinetic and pharmacodynamic data suggest that there are potential benefits of continuous infusion as compared with intermittent boluses. J Crit Care 2014;29:10-7. 1997;25:1969e1975. Found insideThe book Coronary Artery Bypass Graft Surgery is an excellent update for health care professionals, taking care of patients who are being considered for or who have had coronary artery bypass graft surgery. (2020) Diuretic treatment in high-risk acute decompensation of advanced chronic heart failure – bolus intermittent vs. continuous infusion of furosemide: a randomized controlled trial. In addition the effect of low-dose dopamine to improve renal perfusion might be of benefit to this patient cohort. In one volume, this Encylopedia thoroughly covers these ailments and also includes in-depth analysis of less common and rare heart conditions to round out the volume's scope. Crit Care Med 1992;20:17-21. Continuous versus intermittent administration of furosemide in acute decompensated heart failure: a systematic review and meta-analysis. 238 - 247 2010 Mar;16(3):188-93. doi: 10.1016/j.cardfail.2009.11.005. Comparison of continuous versus intermittent furosemide administration in dogs with acute heart failure Zita Filipejová , Carlos Fernando Agudelo Ramírez, Michal Crha University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Small … Continuous versus intermittent furosemide infusion in critically ill infants after open heart operations. This expanded new edition incorporates numerous important updates and new data, bringing together a wealth of important information about drugs commonly used in palliative care and about drugs for use in special circumstances by, or in ... 1992 727. Chest 102 : 725-731 -- Numerous drags have been added to this edition (amphotericin B lipid complex, cefoxitin, fosphenytonin, lamivudine, nevirapine, Vitamin A, Curosurf, Infrasurf, and Similac Human Milk Fortifier) and thirty-six references have been updated ... But a continuous intravenous We performed a prospective randomized crossover study comparing intermittent intravenous administration (IA) of furosemide with continuous infusion following a single loading dose (LDCI) in nine patients with severe congestive heart failure. There is no significant difference in the end points between continuous vs intermittent diuretics. This book describes and discusses the latest research concerning the benefits of having specially trained nurses manage the care of patients with heart failure after they have been discharged from hospital to their own home. This handbook of drugs used in pediatric cardiac care will satisfy the need for a quick reference source of common drug therapy. The aim of the study was to evaluate the efficacy of furosemide in boluses versus continuous infusion in advanced acute heart failure. 2018 Feb;73(2):238-247. doi: 10.1111/anae.14038. 4 However, these differences were entirely driven by the inclusion of a single study of 107 patients for whom the “continuous infusion” … Researchers conducted a new meta-analysis of 10 randomized clinical trials (total patients, 564) to compare the effects of continuous infusion and intermittent bolus of furosemide. Ideal for cardiologists who need to keep abreast of rapidly changing scientific foundations, clinical research results, and evidence-based medicine, Braunwald’s Heart Disease is your indispensable source for definitive, state-of-the-art ... Methods Population and study design. [Epub ahead of print] A reply to "Diuretic treatment in high-risk acute decompensation of advanced chronic heart failure-bolus intermittent vs. continuous infusion of furosemide: a randomized controlled trial". The cIV group experienced a shorter length of hospital stay (6.963.7 versus 10.968.3 days,P5.006). 2005 Jul 20;(3):CD003178 Ann Thorac Surg 1997 ; 64: 1133 – 9 . Presents almost 100 common and uncommon gynecologic problems encountered in urgent and emergency settings with an emphasis on practical management. Crit Care Med. Baseline characteristics were similar between groups (Intermittent Bolus vs Continuous Infusion): Age: 58.7 vs 63 years. Frea S, Pidello S, Volpe A et al. 2019 Oct 11. doi: 10.1007/s00392-019-01551-6. Lahav M, Regev A, Ra anani P, Theodor E. Intermittent administration of furosemide vs continuous infusion preceded by a loading dose for congestive heart failure. Lahav M, Regev A, Ra’anani P, Theodor E 1992: Intermittent administration of furosemide vs continuous infusion preceded by a loading dose for congestive heart failure. New edition of best-selling nursing drug guide Median urine production remained 6.2 ml/kg per hour after 24 hours of con- tinuous furosemide infusion in all patients irrespective of a bolus prior to the continuous furosemide Continuous loop diuretic infusion is sometimes prescribed rather than intermittent bolus therapy . In summary, there was no difference between continuous infusion and bolus of furosemide for all-cause mortality, length of hospital stay and electrolyte disturbance, but continuous infusion was superior to bolus administration with regard to diuretic effect and reduction in brain natriuretic peptide. 3. The change in creatinine from baseline to 72 hours, the primary safety end point, was +0.05 mg/dL for intermittent dosing and +0.07 mg/dL for continuous dosing (p=0.45). Crit Care Med 1992; 20:17-21. This study was a randomized, open-label, single-center trial of twice-daily bolus injection versus continuous infusion… The fourth edition of Donald Plumb's "Veterinary Drug Handbook" remains the resource every veterinarian needs within reach. Throughout, a multidisciplinary approach to pain is stressed. Behavioral and physical therapies, plus ethical considerations, are also discussed in this indispensable guide for anyone involved in the management of pain. This edition of The Management of Sickle Cell Disease (SCD) is organized into four parts: 1. Diagnosis and Counseling 2. Health Maintenance 3. Treatment of Acute and Chronic Complications 4. Special Topics. But crucially hospital was similar with high dose versus low dose, or continuous versus bolus injections of furosemide ( around 5 days). 1. Kuriyama A, Urushidani S Heart Fail Rev 2019 Jan;24(1):31-39. doi: 10.1007/s10741-018-9727-7. 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